PlantPathoEffV1, Main, Exploration, bibRecord, 000180

Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility.

Identifieur interne : 000180 ( Main/Exploration ); précédent : 000179; suivant : 000181

Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility.

Auteurs : Sarah Harvey [Royaume-Uni] ; Priyanka Kumari [Allemagne] ; Dmitry Lapin [Allemagne] ; Thomas Griebel [Allemagne] ; Richard Hickman [Royaume-Uni] ; Wenbin Guo ; Runxuan Zhang ; Jane E. Parker [Allemagne] ; Jim Beynon [Royaume-Uni] ; Katherine Denby [Royaume-Uni] ; Jens Steinbrenner [Allemagne]

Source :

PLoS pathogens [ 1553-7374 ] ; 2020.

RBID : pubmed:32785253

Descripteurs français

KwdFr :
- Arabidopsis (immunologie), Arabidopsis (microbiologie), Facteurs de virulence (génétique), Facteurs de virulence (métabolisme), Immunité des plantes (immunologie), Interactions hôte-pathogène (immunologie), Maladies des plantes (immunologie), Maladies des plantes (microbiologie), Oomycetes (physiologie), Protéines d'Arabidopsis (génétique), Protéines d'Arabidopsis (métabolisme), Régulation de l'expression des gènes végétaux (MeSH), Virulence (MeSH).
MESH :
- génétique : Facteurs de virulence, Protéines d'Arabidopsis.
- immunologie : Arabidopsis, Immunité des plantes, Interactions hôte-pathogène, Maladies des plantes.
- microbiologie : Arabidopsis, Maladies des plantes.
- métabolisme : Facteurs de virulence, Protéines d'Arabidopsis.
- physiologie : Oomycetes.
- Régulation de l'expression des gènes végétaux, Virulence.

English descriptors

KwdEn :
- Arabidopsis (immunology), Arabidopsis (microbiology), Arabidopsis Proteins (genetics), Arabidopsis Proteins (metabolism), Gene Expression Regulation, Plant (MeSH), Host-Pathogen Interactions (immunology), Oomycetes (physiology), Plant Diseases (immunology), Plant Diseases (microbiology), Plant Immunity (immunology), Virulence (MeSH), Virulence Factors (genetics), Virulence Factors (metabolism).
MESH :
- chemical , genetics : Arabidopsis Proteins, Virulence Factors.
- immunology : Arabidopsis, Host-Pathogen Interactions, Plant Diseases, Plant Immunity.
- chemical , metabolism : Arabidopsis Proteins, Virulence Factors.
- microbiology : Arabidopsis, Plant Diseases.
- physiology : Oomycetes.
- Gene Expression Regulation, Plant, Virulence.

Abstract

Hyaloperonospora arabidopsidis (Hpa) is an oomycete pathogen causing Arabidopsis downy mildew. Effector proteins secreted from the pathogen into the plant play key roles in promoting infection by suppressing plant immunity and manipulating the host to the pathogen's advantage. One class of oomycete effectors share a conserved 'RxLR' motif critical for their translocation into the host cell. Here we characterize the interaction between an RxLR effector, HaRxL21 (RxL21), and the Arabidopsis transcriptional co-repressor Topless (TPL). We establish that RxL21 and TPL interact via an EAR motif at the C-terminus of the effector, mimicking the host plant mechanism for recruiting TPL to sites of transcriptional repression. We show that this motif, and hence interaction with TPL, is necessary for the virulence function of the effector. Furthermore, we provide evidence that RxL21 uses the interaction with TPL, and its close relative TPL-related 1, to repress plant immunity and enhance host susceptibility to both biotrophic and necrotrophic pathogens.

DOI: 10.1371/journal.ppat.1008835
PubMed: 32785253
PubMed Central: PMC7446885

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Hyaloperonospora arabidopsidis (Hpa) is an oomycete pathogen causing Arabidopsis downy mildew. Effector proteins secreted from the pathogen into the plant play key roles in promoting infection by suppressing plant immunity and manipulating the host to the pathogen's advantage. One class of oomycete effectors share a conserved 'RxLR' motif critical for their translocation into the host cell. Here we characterize the interaction between an RxLR effector, HaRxL21 (RxL21), and the Arabidopsis transcriptional co-repressor Topless (TPL). We establish that RxL21 and TPL interact via an EAR motif at the C-terminus of the effector, mimicking the host plant mechanism for recruiting TPL to sites of transcriptional repression. We show that this motif, and hence interaction with TPL, is necessary for the virulence function of the effector. Furthermore, we provide evidence that RxL21 uses the interaction with TPL, and its close relative TPL-related 1, to repress plant immunity and enhance host susceptibility to both biotrophic and necrotrophic pathogens.</div>
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<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.ppat.1008835</ELocationID>
<Abstract><AbstractText>Hyaloperonospora arabidopsidis (Hpa) is an oomycete pathogen causing Arabidopsis downy mildew. Effector proteins secreted from the pathogen into the plant play key roles in promoting infection by suppressing plant immunity and manipulating the host to the pathogen's advantage. One class of oomycete effectors share a conserved 'RxLR' motif critical for their translocation into the host cell. Here we characterize the interaction between an RxLR effector, HaRxL21 (RxL21), and the Arabidopsis transcriptional co-repressor Topless (TPL). We establish that RxL21 and TPL interact via an EAR motif at the C-terminus of the effector, mimicking the host plant mechanism for recruiting TPL to sites of transcriptional repression. We show that this motif, and hence interaction with TPL, is necessary for the virulence function of the effector. Furthermore, we provide evidence that RxL21 uses the interaction with TPL, and its close relative TPL-related 1, to repress plant immunity and enhance host susceptibility to both biotrophic and necrotrophic pathogens.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Harvey</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Biology, University of York, York, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kumari</LastName>
<ForeName>Priyanka</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Institut für Phytopathologie, Universität Gießen, Gießen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lapin</LastName>
<ForeName>Dmitry</ForeName>
<Initials>D</Initials>
<Identifier Source="ORCID">0000-0001-9591-3950</Identifier>
<AffiliationInfo><Affiliation>Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg, Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Cluster of Excellence in Plant Sciences (CEPLAS), Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Griebel</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<Identifier Source="ORCID">0000-0002-3600-6493</Identifier>
<AffiliationInfo><Affiliation>Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg, Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Dahlem Center of Plant Sciences, Plant Physiology, Freie Universität Berlin, Berlin, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hickman</LastName>
<ForeName>Richard</ForeName>
<Initials>R</Initials>
<Identifier Source="ORCID">0000-0002-4542-7740</Identifier>
<AffiliationInfo><Affiliation>Department of Biology, University of York, York, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Wenbin</ForeName>
<Initials>W</Initials>
<Identifier Source="ORCID">0000-0002-1829-6044</Identifier>
<AffiliationInfo><Affiliation>The James Hutton Institute, Invergowrie, Dundee, Scotland United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Runxuan</ForeName>
<Initials>R</Initials>
<Identifier Source="ORCID">0000-0001-7558-765X</Identifier>
<AffiliationInfo><Affiliation>The James Hutton Institute, Invergowrie, Dundee, Scotland United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Parker</LastName>
<ForeName>Jane E</ForeName>
<Initials>JE</Initials>
<Identifier Source="ORCID">0000-0002-4700-6480</Identifier>
<AffiliationInfo><Affiliation>Max Planck Institute for Plant Breeding Research, Carl-von-Linné-Weg, Cologne, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Cluster of Excellence in Plant Sciences (CEPLAS), Cologne, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Beynon</LastName>
<ForeName>Jim</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">0000-0002-1855-3215</Identifier>
<AffiliationInfo><Affiliation>School of Life Sciences, University of Warwick, Coventry, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Denby</LastName>
<ForeName>Katherine</ForeName>
<Initials>K</Initials>
<Identifier Source="ORCID">0000-0002-7857-6814</Identifier>
<AffiliationInfo><Affiliation>Department of Biology, University of York, York, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Steinbrenner</LastName>
<ForeName>Jens</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">0000-0003-1008-2268</Identifier>
<AffiliationInfo><Affiliation>Institut für Phytopathologie, Universität Gießen, Gießen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>BB/K018612/1</GrantID>
<Acronym>BB_</Acronym>
<Agency>Biotechnology and Biological Sciences Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>BB/K018612/2</GrantID>
<Acronym>BB_</Acronym>
<Agency>Biotechnology and Biological Sciences Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>12</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS Pathog</MedlineTA>
<NlmUniqueID>101238921</NlmUniqueID>
<ISSNLinking>1553-7366</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D029681">Arabidopsis Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D037521">Virulence Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C511291">topless protein, Arabidopsis</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D017360" MajorTopicYN="N">Arabidopsis</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029681" MajorTopicYN="N">Arabidopsis Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018506" MajorTopicYN="N">Gene Expression Regulation, Plant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009868" MajorTopicYN="N">Oomycetes</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057865" MajorTopicYN="N">Plant Immunity</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D037521" MajorTopicYN="N">Virulence Factors</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>The authors have declared that no competing interests exist.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>05</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>08</Month>
<Day>24</Day>
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<Month>8</Month>
<Day>14</Day>
<Hour>6</Hour>
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<Month>9</Month>
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<Hour>6</Hour>
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	Serveur d'exploration sur les effecteurs de phytopathogènes
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les effecteurs de phytopathogènes

Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility.

Downy Mildew effector HaRxL21 interacts with the transcriptional repressor TOPLESS to promote pathogen susceptibility.

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